Children in the HOPE VI Panel Study sample face enormous challenges in becoming successful adults. Despite these challenges, some children do surprisingly well and seem able to cope effectively with the challenges in their environment. This report reviews existing research from a range of social science disciplines to identify key factors related to resiliency and to understand how these factors protect children from negative outcomes. Then, using data from the HOPE VI Panel Study, we explore which of these factors are related to resiliency in our sample of children from HOPE VI developments.