Community-based nonprofit organizations traditionally use public and philanthropic funding to fund programming. Often, these organizations operate on thin margins and lack financial sustainability. This case study examines how a Washington, DC–based community health and research center pursued an innovative venture to redevelop its outdated flagship clinic into a revenue-generating, multi-use development that will support existing operations and enable the clinic to expand services. With insights from stakeholders involved in the project, we detail the conceptualization and financing of the venture, discuss lessons learned, and provide recommendations for nonprofits interested in replicating this model.