Government agencies want to operate efficient and effective services. Agency staff often understand the importance of learning and improvement to increase their services’ value for taxpayers, improve communities, reduce waste, fix problems, support families, and many other essential functions. Even when staff want to improve their results, it can be difficult to figure out where to focus, and especially how to systematically decide where to pay the most attention and why. This brief will help government managers use implementation science to systematically identify opportunities to improve operations, achieve their missions, and—if in the federal government—implement the Foundations for Evidence Based Policy Making Act of 2018 (Evidence Act).