Two-generation models target low-income children and their parents in hopes of interrupting the cycle of poverty. These models vary widely, and policymakers and practitioners need guidance on how best to design them. This brief uses insights from the Housing Opportunities and Services Together Demonstration to present an updated theoretical framework for these models. The framework emphasizes the importance of using family goals to target individual family members, setting individual goals, and aligning tailored and appropriate solutions. This lens also emphasizes prioritizing relationship-building over programs and designing flexible evaluation approaches, while working for systems change to support families in their efforts.