Many young people in the United States do not have the literacy and numeracy skills required to succeed in postsecondary education and training or to find gainful employment. This report presents findings from an exploratory study of strategies, approaches, and practices to support building the literacy and numeracy skills of out-of-school youth, based on a review of the literature and interviews with staff from 12 youth-serving organizations. We find that organizations interviewed are taking an individual-oriented approach to teaching literacy and numeracy, leveraging technology, and balancing various considerations in meeting young people’s needs. We conclude that increased communication and more standards of practice for youth literacy and numeracy development programs would likely be beneficial, perhaps through a professional learning community.