Public-private partnerships (PPPs) are a contracting model that can help governments leverage the financial and technical capabilities of private sector partners to address urgent service and infrastructure needs, including health and health-affecting services such as water and sanitation. This brief provides guidance for local leaders exploring potential PPP projects for urban health and reviews the PPP landscape in three Asian cities: Indore, India; Makassar, Indonesia; and Da Nang, Vietnam. Informed by a review of literature and expert interviews, the brief describes four recommended steps for local leaders to take to explore and build strong urban health PPP portfolios: (1) assess the environment for PPPs; (2) adopt an objective approach to assess the merits of individual projects; (3) use that approach to build a pipeline of projects; and (4) evaluate and build on successes. The brief also shares resources for local leaders to learn more about the PPP model and to start building a PPP project portfolio. This guidance brief accompanies a PPP primer brief that provides (1) an introduction of the PPP model, (2) an overview of its benefits and challenges, and (3) a discussion on how it can be used to advance urban health.