During the 1990s, the Department of Housing and Urban Development launched three rigorous research demonstrations testing alternative strategies for helping low-income families escape the isolation and distress of high-poverty, central-city communities. All three demonstrations were carefully designed to include rigorous controls and systematic data collection so that their implementation and impacts could be systematically evaluated. And all three are now generating provocative results that offer new insights for ongoing program experimentation and policy development. We draw ten broad lessons--including lessons about the potential for success, about the realities families face, about implementing complex strategies, and about obstacles to success.