This guide encourages community stakeholders to organize events around the 500 Cities data—27 indicators of adult health status, unhealthy behaviors, and prevention available at the census-tract level for 500 of America’s largest cities . Building on the success of a national convening sponsored by the Robert Wood Johnson Foundation (RWJF) in December 2016, the suggestions here focus on engaging diverse audiences, learning about the data, and generating ideas on how to use the data to advance health. For more information, see the related webinar recording, which features a review of the guide by the authors and advice from a local community organization that hosted a 500 Cities event.