Across two rounds of grants, the Health Profession Opportunity Grants (HPOG) Program aimed to provide education and training to Temporary Assistance for Needy Families (TANF) recipients and other adults with low incomes for occupations in the healthcare field that pay well and are expected to either experience labor shortages or be in high demand. The Administration for Children and Families (ACF) within the U.S. Department of Health and Human Services awarded the first round of five-year HPOG grants (HPOG 1.0) in 2010. The second round of five-year grants (HPOG 2.0) was awarded in 2015, with grant funds disbursed annually to 32 grantees in 21 states, including five Tribal organizations. The grants were later extended through September 29, 2021. This Final Annual Report describes results over the entirety of HPOG 2.0 (September 30, 2015, to September 29, 2021).