The Health Profession Opportunity Grants (HPOG) Program, established by the Affordable Care Act of 2010, funds training programs in high-demand healthcare professions, targeted to Temporary Assistance for Needy Families (TANF) recipients and other low-income individuals. In 2010, the Administration for Children and Families of the U.S. Department of Health and Human Services awarded 32 HPOG grantees in 23 states with five-year grants. This Annual Report provides an overview of HPOG grantees, characteristics of participants, activities in which participants were engaged, training and employment outcomes, and how grantee programs continued to evolve in the second year of the program.