The Healthy Neighborhoods Healthy Families (HNHF) initiative, created by Nationwide Children’s Hospital, seeks to remove barriers to the health and well-being of families in Columbus, Ohio’s South Side neighborhood. The initiative facilitates access to affordable housing, quality education, health and wellness programs, safe and accessible neighborhoods, and workforce development opportunities. In 2008, Nationwide partnered with Community Development for All People (CD4AP), a nonprofit community development organization, and launched HNHF Realty Collaborative, a real estate subsidiary to rehabilitate existing housing stock and develop new affordable homes on vacant lots. This case study highlights the role that anchor institutions can play in addressing housing as a social determinant of health and the value of community development corporations in providing on-the-ground housing expertise. This case study is part of a larger report on Emerging Strategies for Integrating Health and Housing