This is the final report of the National Implementation Evaluation (NIE) of the Health Profession Opportunity Grants (HPOG). In 2010, the U.S. Department of Health and Human Services awarded the first round of 5-year HPOG grants (HPOG 1.0) to 32 organizations in 23 states to provide education and training to Temporary Assistance for Needy Families (TANF) recipients and other low-income individuals for occupations in the healthcare field that pay well and are expected to experience labor shortages or be in high demand. This report summarizes HPOG 1.0 training and services offered to and received by participants and describes the education, employment, and earnings outcomes for participants.