This brief describes how Promise Neighborhoods can apply an equity lens to address disparate outcomes as a path to achieving better results for all children and families. Promise Neighborhoods is a federal initiative that aims to improve the educational and developmental outcomes of children and families in diverse communities, including urban neighborhoods, rural areas, and tribal lands. Effective Promise Neighborhoods follow a performance management cycle—that is, steps to align services with the needs of individuals and families and to track and improve progress and results. Within these cycles are critical opportunities to address disparities. We introduce concepts such as data segmentation, cocreation, and targeted universalism to help leaders bring a more powerful equity lens to planning and implementing initiatives focused on improving social and educational outcomes for all students.