About 65 percent of college presidents identified fall 2020 enrollment numbers as a key issue for their campuses. As many schools return with virtual or limited face-to-face coursework, college enrollment patterns could change substantially. I use national data on higher education enrollment to understand how changes in certain student populations, such as international students or students receiving Pell grants, affect overall enrollment. The effects of these changes will be felt differently across sectors and geographic areas. Policymakers could use these models to prioritize support for higher education in the face of broad changes in enrollment.