This brief explores vulnerability, precariousness, and resilience as they apply to people, housing, neighborhoods, and metropolitan areas. We document the relationships between potential personal or household vulnerability and potentially precarious housing conditions. Microdata from the American Community Survey suggest that an important minority of people have multiple vulnerabilities; these vulnerabilities associate with residence in precarious housing. By beginning from the level of individuals, we build the groundwork for a more robust approach toward tackling concentrated disadvantage within the context of fostering resilient regions. We suggest that policy be directed toward precarious situations most likely to afflict the most vulnerable populations.