This brief summarizes common themes across two studies of local Head Start programs and a multidisciplinary literature review. The brief provides preliminary evidence that Head Start programs experience similar challenges and facilitators to data use for continuous quality improvement as those experienced in other fields including leadership, analytic capacity, commitment of resources, professional development, a culture of collaborative inquiry, a continuous cycle of data use, and organizational and environmental characteristics. The brief provides an overview of findings and poses questions for future research to better understand the relationships between the elements examined and Head Start characteristics and data use strategies.