Low high school graduation rates and sharply declining employment rates continue to plague disadvantaged youth, especially young men. We review the evidence base on programs and policies such as youth development for adolescents and young teens; programs seeking to improve educational attainment and employment for in-school youth; and programs that try to "reconnect" those who are out of school and frequently out of work, including public employment programs. We identify a number of programmatic strategies that are promising or even proven, based on rigorous evaluations, for disadvantaged youth with different circumstances.