In Boston, Massachusetts, the Boston Housing Authority, Boston Public Health Commission, the city’s Inspectional Services Department, the Boston Foundation, and local universities and medical institutions have come together over the last decade-plus to address the intersection of health and housing. Motivated by a desire to improve the lives of Boston’s most vulnerable residents, these organizations began collaborating to address asthma and, more recently, to prioritize housing and health needs for pregnant women. By bridging anchor institutions, foundations, and city agencies around health and housing initiatives citywide, Boston has made strides toward providing healthier housing options and integrated health management and referral systems. This case study highlights how a variety of key stakeholders within one city can collaborate to address the health and housing needs of its vulnerable residents. This case study is part of a larger report on Emerging Strategies for Integrating Health and Housing