A central goal of U.S. social welfare policy is to ensure that all children have the opportunity to reach their full potential as productive adults. Yet it is increasingly clear that where children live plays a central role in determining their life chances. This paper provides an overview of The Urban Institute's Program on Neighborhoods and Youth Development, which is dedicated to understanding the relationships between neighborhood-level factors and the well-being and development of children and youth and identifying and evaluating place-based, community-wide strategies to help children grow up to reach their full potential as adults.